Protein name:
Integrin alpha-1 ;
Alternative:
Laminin and collagen receptor ;CD49 antigen-like family member A ;VLA-1 ;
CD:
CD49a ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1. Interacts with RAB21.
Function:
Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MAPRPRARPG | VAVACCWLLT | VVLRCCVSFN | VDVKNSMTFS | GPVEDMFGYT |
100:
VQQYENEEGK | WVLIGSPLVG | QPKNRTGDVY | KCPVGRGESL | PCVKLDLPVN |
150:
TSIPNVTEVK | ENMTFGSTLV | TNPNGGFLAC | GPLYAYRCGH | LHYTTGICSD |
200:
VSPTFQVVNS | IAPVQECSTQ | LDIVIVLDGS | NSIYPWDSVT | AFLNDLLERM |
250:
DIGPKQTQVG | IVQYGENVTH | EFNLNKYSST | EEVLVAAKKI | VQRGGRQTMT |
300:
ALGIDTARKE | AFTEARGARR | GVKKVMVIVT | DGESHDNHRL | KKVIQDCEDE |
350:
NIQRFSIAIL | GSYNRGNLST | EKFVEEIKSI | ASEPTEKHFF | NVSDELALVT |
400:
IVKTLGERIF | ALEATADQSA | ASFEMEMSQT | GFSAHYSQDW | VMLGAVGAYD |
450:
WNGTVVMQKA | SQIIIPRNTT | FNVESTKKNE | PLASYLGYTV | NSATASSGDV |
500:
LYIAGQPRYN | HTGQVIIYRM | EDGNIKILQT | LSGEQIGSYF | GSILTTTDID |
550:
KDSNTDILLV | GAPMYMGTEK | EEQGKVYVYA | LNQTRFEYQM | SLEPIKQTCC |
600:
SSRQHNSCTT | ENKNEPCGAR | FGTAIAAVKD | LNLDGFNDIV | IGAPLEDDHG |
650:
GAVYIYHGSG | KTIRKEYAQR | IPSGGDGKTL | KFFGQSIHGE | MDLNGDGLTD |
700:
VTIGGLGGAA | LFWSRDVAVV | KVTMNFEPNK | VNIQKKNCHM | EGKETVCINA |
750:
TVCFDVKLKS | KEDTIYEADL | QYRVTLDSLR | QISRSFFSGT | QERKVQRNIT |
800:
VRKSECTKHS | FYMLDKHDFQ | DSVRITLDFN | LTDPENGPVL | DDSLPNSVHE |
850:
YIPFAKDCGN | KEKCISDLSL | HVATTEKDLL | IVRSQNDKFN | VSLTVKNTKD |
900:
SAYNTRTIVH | YSPNLVFSGI | EAIQKDSCES | NHNITCKVGY | PFLRRGEMVT |
950:
FKILFQFNTS | YLMENVTIYL | SATSDSEEPP | ETLSDNVVNI | SIPVKYEVGL |
1000:
QFYSSASEYH | ISIAANETVP | EVINSTEDIG | NEINIFYLIR | KSGSFPMPEL |
1050:
KLSISFPNMT | SNGYPVLYPT | GLSSSENANC | RPHIFEDPFS | INSGKKMTTS |
1100:
TDHLKRGTIL | DCNTCKFATI | TCNLTSSDIS | QVNVSLILWK | PTFIKSYFSS |
1150:
LNLTIRGELR | SENASLVLSS | SNQKRELAIQ | ISKDGLPGRV | PLWVILLSAF |
1179:
AGLLLLMLLI | LALWKIGFFK | RPLKKKMEK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Chicken
ELISA Kit for Human Integrin alpha-1
ELISA Kit for Human Integrin alpha-1
ELISA Kit for Human Integrin alpha-1
ELISA Kit for Human Integrin alpha-1
CLIA Kit for Human Integrin alpha-1
CLIA Kit for Human Integrin alpha-1
CLIA Kit for Human Integrin alpha-1
CLIA Kit for Human Integrin alpha-1
Polyclonal Antibody for Human Integrin alpha-1
Polyclonal Antibody for Human Integrin alpha-1
Polyclonal Antibody for Human Integrin alpha-1
Polyclonal Antibody for Human Integrin alpha-1
Monoclonal Antibody for Human Integrin alpha-1
Monoclonal Antibody for Human Integrin alpha-1
Monoclonal Antibody for Human Integrin alpha-1
Monoclonal Antibody for Human Integrin alpha-1
Protein for Human Integrin alpha-1
Protein for Human Integrin alpha-1
Protein for Human Integrin alpha-1
Protein for Human Integrin alpha-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J.
,
Martin J.
,
Terry A.
,
Couronne O.
,
Grimwood J.
,
Lowry S.
,
Gordon L.A.
,
Scott D.
,
Xie G.
,
Huang W.
,
Hellsten U.
,
Tran-Gyamfi M.
,
She X.
,
Prabhakar S.
,
Aerts A.
,
Altherr M.
,
Bajorek E.
,
Black S.
,
Branscomb E.
,
Caoile C.
,
Challacombe J.F.
,
Chan Y.M.
,
Denys M.
,
Detter J.C.
,
Escobar J.
,
Flowers D.
,
Fotopulos D.
,
Glavina T.
,
Gomez M.
,
Gonzales E.
,
Goodstein D.
,
Grigoriev I.
,
Groza M.
,
Hammon N.
,
Hawkins T.
,
Haydu L.
,
Israni S.
,
Jett J.
,
Kadner K.
,
Kimball H.
,
Kobayashi A.
,
Lopez F.
,
Lou Y.
,
Martinez D.
,
Medina C.
,
Morgan J.
,
Nandkeshwar R.
,
Noonan J.P.
,
Pitluck S.
,
Pollard M.
,
Predki P.
,
Priest J.
,
Ramirez L.
,
Retterer J.
,
Rodriguez A.
,
Rogers S.
,
Salamov A.
,
Salazar A.
,
Thayer N.
,
Tice H.
,
Tsai M.
,
Ustaszewska A.
,
Vo N.
,
Wheeler J.
,
Wu K.
,
Yang J.
,
Dickson M.
,
Cheng J.-F.
,
Eichler E.E.
,
Olsen A.
,
Pennacchio L.A.
,
Rokhsar D.S.
,
Richardson P.
,
Lucas S.M.
,
Myers R.M.
,
Rubin E.M.
more...
Nature431:268-274(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 29-1179
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-532
tissue :
Plasma .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN EGFR SIGNALING;INTERACTION WITH PTPN2
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RAB21
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-100; ASN-105; ASN-217; ASN-341; ASN-418; ASN-460; ASN-532; ASN-780; ASN-840; ASN-966; ASN-974 AND ASN-1008
tissue :
Liver .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
9.
"Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus cna MSCRAMM."
Rich R.L.
,
Deivanayagam C.C.
,
Owens R.T.
,
Carson M.
,
Hook A.
,
Moore D.
,
Symersky J.
,
Yang V.W.
,
Narayana S.V.
,
Hook M.
J. Biol. Chem.274:24906-24913(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 168-359
10.
"Jararhagin-derived RKKH peptides induce structural changes in alpha1I domain of human integrin alpha1beta1."
Nymalm Y.
,
Puranen J.S.
,
Nyholm T.K.
,
Kapyla J.
,
Kidron H.
,
Pentikainen O.T.
,
Airenne T.T.
,
Heino J.
,
Slotte J.P.
,
Johnson M.S.
,
Salminen T.A.
J. Biol. Chem.279:7962-7970(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.87 ANGSTROMS) OF 166-356